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Updated: Jun 25, 2026
Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
Published on: October 26, 2016
Prospective multicenter study for evaluation of safety, efficacy, and esthetic results of cross-linked polyacrylamide
Marianne Wolters1, Hermann Lampe
1Liebigstrasse 8, Frankfurt, Germany. info@plastische-chirurgie-ffm.de
Background:
Cross-linked polyacrylamide hydrogel, a nonabsorbable soft-tissue filler, has given promising results regarding efficacy and safety at 24 months of follow-up, but because adverse reactions have been described years after injection of some other fillers, a prolonged follow-up was required.
Objective:
To examine the safety and efficacy of the hydrogel in facial contouring after 36 to 48 months (mean 40 months).
Methods:
In this prospective multicenter trial, the esthetic results and safety of the treatments were assessed at 36 to 48 months, and the results were compared with those seen previously.
Results:
Eighty-one patients participated. The investigator rated esthetic results as very good or good in 99% of cases, and 98% of patients rated esthetic results as very satisfactory or satisfactory. Two of nine reported adverse events were possibly related to hydrogel treatment. One was initial infection after a touch-up, and one was continuous itching 1 year after injection.
Conclusion:
The polyacrylamide hydrogel filler was still well tolerated after 36 to 48 months with no long-term unexpected adverse events and no loss of filler effect.