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Related Concept Videos

Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Production of Formed Elements01:34

Production of Formed Elements

Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...

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Related Experiment Video

Updated: Jun 25, 2026

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery
08:43

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Published on: February 14, 2017

Endothelial progenitor cells - hype or hope?

J D Pearson1

  • 1King's College London, Cardiovascular Division, London, UK. jeremy.pearson@kcl.ac.uk

Journal of Thrombosis and Haemostasis : JTH
|February 12, 2009
PubMed
Summary

Endothelial progenitor cells (EPCs) were initially thought to repair tissues by forming new blood vessels. However, research shows these cells primarily aid angiogenesis through secreted factors, not direct vessel formation.

Area of Science:

  • Regenerative Medicine
  • Cardiovascular Research
  • Cell Biology

Background:

  • Discovery of endothelial progenitor cells (EPCs) shifted understanding of angiogenesis from local endothelial cell activity to circulating bone marrow-derived cells.
  • EPCs offered potential for tissue repair and re-endothelialization after ischemic vascular injury, particularly myocardial infarction (MI).

Purpose of the Study:

  • To review current knowledge of EPCs and their function in angiogenesis.
  • To discuss the properties of genuine endothelial progenitor cells.
  • To explore future therapeutic applications for enhanced angiogenesis.

Main Methods:

  • Review of existing scientific literature on endothelial progenitor cells.
  • Analysis of clinical study outcomes regarding EPC-based therapies for MI.

More Related Videos

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood
07:26

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood

Published on: September 14, 2017

Phenotypic and Functional Characterization of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood
13:46

Phenotypic and Functional Characterization of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood

Published on: April 13, 2012

Related Experiment Videos

Last Updated: Jun 25, 2026

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery
08:43

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Published on: February 14, 2017

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood
07:26

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood

Published on: September 14, 2017

Phenotypic and Functional Characterization of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood
13:46

Phenotypic and Functional Characterization of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood

Published on: April 13, 2012

  • Comparison of identified EPCs with genuine endothelial progenitor cells.

    • Main Results:

    • Clinical studies using bone marrow-derived EPCs for ischemic injury yielded modest results.
    • Subsequent research indicated that the studied EPCs are not true endothelial progenitors.
    • These cells likely contribute to angiogenesis via paracrine factor release.

    Conclusions:

    • The therapeutic efficacy of initially identified EPCs is limited.
    • Genuine endothelial progenitor cells possess distinct properties for future therapeutic development.
    • Future strategies will focus on leveraging true endothelial progenitors for effective therapeutic angiogenesis.