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Updated: Jun 25, 2026

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

Metastatic parachordoma.

Alex Guedes¹, Bruno G Barreto, Lara G S Barreto

¹Department of Musculoskeletal Cancer Surgery, Santa Izabel Hospital, Salvador, Brazil.

Journal of Cutaneous Pathology

|February 12, 2009

Summary

This summary is machine-generated.

Metastatic parachordomas are rare, aggressive soft tissue tumors. This case highlights an unusual pediatric presentation with unexpected chromogranin A expression, challenging current classifications.

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Last Updated: Jun 25, 2026

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

Area of Science:

Oncology
Pathology
Pediatric Neoplasms

Background:

Parachordomas are typically rare, indolent soft tissue neoplasms.
Understanding the behavior and classification of rare tumors is crucial for effective treatment.

Observation:

A 6-year-old girl presented with a large left forearm mass (11 x 6 cm) with moderate nuclear atypia and necrosis.
Lung metastases were detected three months post-diagnosis, indicating aggressive behavior.

Findings:

Immunophenotyping revealed diffuse pancytokeratin, S-100 protein, vimentin, and glial fibrillary acidic protein expression.
Focal chromogranin A expression was observed, which is unexpected for parachordomas.

Implications:

This case represents the fifth report of metastasized parachordoma and the first with focal chromogranin A positivity.
The findings prompt a re-evaluation of the relationship between parachordomas, myoepitheliomas, and pediatric myoepithelial carcinoma.