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Related Experiment Video

Updated: Jun 25, 2026

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease

Published on: October 14, 2021

Alpha-methyldopa hepatotoxicity in pregnancy.

Tauseef Ali¹, Nandakumar Srinivasan, Vu Le

¹Department of Gastroenterology, University of Oklahoma, Oklahoma City, USA. tauseef-ali@ouhsc.edu

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

|February 12, 2009

Summary

Methyldopa can cause liver injury in pregnancy, presenting as jaundice. Prompt diagnosis and treatment with corticosteroids resolved the methyldopa-induced hepatitis.

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Area of Science:

Hepatology
Pharmacology
Obstetrics

Background:

Methyldopa is a common antihypertensive medication used during pregnancy.
Drug-induced liver injury (DILI) is a significant concern in pregnant patients.
Hepatotoxicity from methyldopa, though rare, requires careful consideration.

Observation:

A 33-year-old pregnant female presented with jaundice and elevated liver enzymes.
Investigations ruled out viral and autoimmune hepatitis.
Methyldopa was identified as the likely causative agent for hepatitis.

Findings:

The patient developed methyldopa-induced hepatitis during pregnancy.
Treatment with corticosteroids led to normalization of liver function tests.
This case highlights the importance of considering drug-induced causes of hepatitis.

Implications:

Clinicians should be vigilant for methyldopa-induced hepatotoxicity in pregnant patients.
Early recognition and management are crucial for favorable outcomes.
This case underscores the need for comprehensive drug-induced liver injury evaluations.