Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Fibrin monomer assay].

H Kobayashi1, M Matsuo, K Ikeguchi

  • 1Central Laboratory, Hyogo prefectural Awaji Hospital, Sumoto.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|July 1, 1991
PubMed
Summary

Fibrin monomer (FM) assays detect early coagulopathy in disseminated intravascular coagulation (DIC) before other markers rise. FM reflects actual thrombin generation, offering a more reliable indicator than TAT in DIC patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Expandable metallic stent therapy for SVC syndrome--effects on local venous pressure, vascular diameter, symptoms, and these correlations].

Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica·1992
Same author

[Biological effects of static gradient magnetic field on cultured mammalian cells and combined effects with 60Co gamma-rays].

Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica·1992
Same author

Bleomycin but not its derivatives inhibits the in vivo shedding of a rat tumor-associated antigen.

Anti-cancer drugs·1992
Same author

Isolation of cDNA for bovine stomach 155 kDa protein exhibiting myosin light chain kinase activity.

Journal of biochemistry·1992
Same author

Escherichia coli is able to grow with negligible sodium ion extrusion activity at alkaline pH.

Journal of bacteriology·1992
Same author

Cooperative modulation of voltage-dependent sodium channels by brevetoxin and classical neurotoxins in cultured bovine adrenal medullary cells.

The Journal of pharmacology and experimental therapeutics·1992

Area of Science:

  • Coagulation science
  • Hematology
  • Biochemistry

Context:

  • Disseminated intravascular coagulation (DIC) is a complex hematological disorder.
  • Early detection of DIC is crucial for effective management.
  • Traditional markers like FDP and D-dimer may not show significant changes in early stages.

Purpose:

  • To evaluate the utility of a quantitative fibrin monomer (FM) assay in detecting early coagulopathy in patients prone to DIC.
  • To compare the sensitivity of FM assay with established markers like FDP and D-dimer.
  • To assess the impact of Antithrombin III (AT III) concentrate administration on FM and thrombin-antithrombin complex (TAT) levels.

Summary:

  • A chromogenic substrate assay (S-2390) was used to quantify fibrin monomer (FM).
  • Patients prone to DIC were grouped, with the pre-DIC group showing elevated FM levels compared to controls, while FDP and D-dimer remained unchanged.
  • Administration of AT III concentrate in cases of low plasma ATIII led to a transient rise in TAT, highlighting FM's ability to reflect real-time thrombin generation.

Impact:

  • FM assay serves as a valuable marker for the early detection of coagulopathy in DIC.
  • FM assay provides a more accurate reflection of thrombin generation compared to TAT, which can be influenced by fluctuating ATIII levels.
  • This research contributes to improved diagnostic strategies for DIC, potentially leading to earlier intervention and better patient outcomes.

Related Experiment Videos