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Related Experiment Videos

[Thrombin.antithrombin III complex].

T Matsuo1, K Kario, M Matsuo

  • 1Central Laboratory, Hyogo Prefectural Awaji Hospital, Sumoto.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|July 1, 1991
PubMed
Summary

Thrombin-antithrombin complex (TAT) levels increase in disseminated intravascular coagulation (DIC). Early detection of pre-DIC is possible with TAT monitoring, and anticoagulants like heparin or MD805 effectively manage high TAT levels.

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Area of Science:

  • Hematology
  • Coagulation science
  • Thrombosis research

Background:

  • Thrombin-antithrombin complex (TAT) is a marker of thrombin generation.
  • Disseminated intravascular coagulation (DIC) involves widespread micro-thrombus formation and can lead to increased TAT.
  • Pre-DIC stages may exhibit elevated TAT, indicating hypercoagulability.

Purpose of the Study:

  • To investigate the role of TAT in DIC and pre-DIC states.
  • To evaluate the efficacy of anticoagulants in managing elevated TAT.
  • To explore therapeutic strategies for ATIII-deficient DIC.

Main Methods:

  • Classification of DIC patients into three groups based on screening tests (FDP, platelet count, fibrinogen, prothrombin time).
  • Measurement and comparison of TAT levels in control, pre-DIC, and DIC groups.
  • Administration of anticoagulants (heparin, ATIII concentrate, MD805) and assessment of their effect on TAT levels.
  • Evaluation of tranexamic acid for managing bleeding complications.

Main Results:

  • TAT levels were significantly higher in pre-DIC compared to controls.
  • Anticoagulant therapy, including heparin, effectively lowered TAT.
  • In ATIII-deficient DIC, ATIII concentrate substitution reduced TAT, and MD805, a synthetic thrombin inhibitor, also decreased TAT without ATIII administration.
  • Tranexamic acid alleviated bleeding complications associated with high alpha 2 plasmin inhibitor plasmin complex levels.

Conclusions:

  • Elevated TAT is a sensitive indicator for detecting pre-DIC.
  • Anticoagulants are effective in managing high TAT in DIC.
  • MD805 offers a viable therapeutic option for high TAT in ATIII-deficient DIC.
  • Combined therapy may be necessary to manage complex DIC-related complications.

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