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[Factor XIa-alpha 1 antitrypsin complex].

H Egawa1, Y Komiyama, H Nishikado

  • 1Department of Clinico-Laboratory Medicine, Kansai Medical University, Moriguchi.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|July 1, 1991
PubMed
Summary
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A new assay detects factor XIa-alpha 1 antitrypsin complex (FXIa-alpha 1AT). Elevated FXIa-alpha 1AT levels correlate with aging and indicate disseminated intravascular coagulation (DIC).

Area of Science:

  • Biochemistry
  • Hematology
  • Clinical Diagnostics

Background:

  • Disseminated intravascular coagulation (DIC) is a complex thrombotic disorder.
  • Accurate and rapid diagnostic markers for DIC are crucial for timely intervention.
  • Existing markers like FDP-E and alpha 2PI-PmC have limitations in early detection.

Observation:

  • A novel assay was developed to quantify the factor XIa-alpha 1 antitrypsin complex (FXIa-alpha 1AT) in plasma.
  • The assay utilizes a specific anti-FXI monoclonal antibody (KMXI-1) and functions effectively in diluted plasma.
  • FXIa-alpha 1AT levels were observed to increase with age in healthy adults.

Findings:

  • Normal FXIa-alpha 1AT levels in healthy adults were determined to be 11 +/- 4.1 ng/ml.
  • Patients with DIC exhibited rising FXIa-alpha 1AT levels correlating with disease progression.

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  • The onset and peak of elevated FXIa-alpha 1AT levels appeared earlier than other markers (FDP-E, alpha 2PI-PmC) in most DIC patients.

    • Implications:

    • FXIa-alpha 1AT serves as a valuable molecular marker for diagnosing DIC.
    • This assay offers a potentially faster diagnostic tool compared to existing methods.
    • Further research can explore the clinical utility of FXIa-alpha 1AT in managing DIC and other coagulation disorders.