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Related Concept Videos

Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
Zygotic Development And Stem Cell Formation01:10

Zygotic Development And Stem Cell Formation

The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...

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Updated: Jun 25, 2026

Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens
09:15

Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens

Published on: May 23, 2014

Somatic stem cells in the endometrium.

Irene Cervelló1, Carlos Simón

  • 1Fundación IVI, Instituto Universitario IVI, Universidad de Valencia, Valencia, Spain. icervello@hotmail.com

Reproductive Sciences (Thousand Oaks, Calif.)
|February 12, 2009
PubMed
Summary
This summary is machine-generated.

Endometrial stem cells, crucial for tissue regeneration, have been recently identified in both mouse and human endometria. These somatic stem cells reside within the basalis layer, specifically in the stromal and epithelial compartments.

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Published on: May 23, 2014

Generation of Multicellular Human Primary Endometrial Organoids
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Area of Science:

  • Reproductive biology
  • Stem cell research
  • Gynecology

Background:

  • The human endometrium undergoes cyclical regeneration, suggesting a role for stem cells.
  • The concept of endometrial stem cells has been theorized for years.
  • Recent research focuses on identifying these cells and their location.

Purpose of the Study:

  • To identify and characterize somatic stem cells within the human and murine endometria.
  • To determine the specific location (niche) of these endometrial stem cells.

Main Methods:

  • Histological analysis of endometrial tissue.
  • Cellular identification techniques to detect stem cell markers.
  • Microscopic examination of the basalis layer.

Main Results:

  • Somatic stem cells with regenerative potential have been identified in human and murine endometria.
  • The stem cell niche is localized to the stromal and epithelial compartments of the basalis layer.

Conclusions:

  • Endometrial stem cells are confirmed to exist and play a role in tissue regeneration.
  • The basalis layer's stromal and epithelial cells represent the niche for these critical stem cells.