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Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

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Cancer

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Drug Discovery: Overview

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Related Experiment Video

Updated: Jun 25, 2026

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

Is anticancer drug development heading in the right direction?

Trevor W Hambley¹, William N Hait

¹School of Chemistry, The University of Sydney, New South Wales, Australia. t.hambley@chem.usyd.edu.au

Cancer Research

|February 12, 2009

Summary

Molecularly targeted agents show promise, but imatinib

Area of Science:

Oncology and Drug Development

Background:

The success of imatinib has spurred interest in molecularly targeted agents for cancer therapy.
However, limited successes suggest this approach may not be universally applicable.

Purpose of the Study:

To evaluate the current landscape of anticancer drug development strategies.
To advocate for a diversified approach beyond solely molecular targeting.

Main Methods:

Review of recent clinical trial outcomes for targeted therapies.
Analysis of the success rates of imatinib in chronic myelogenous leukemia and gastrointestinal stromal tumor.

Main Results:

The number of successful molecularly targeted agents remains small.
Imatinib's success in specific cancers may be exceptional, not representative of the broader class.

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Assessing Specificity of Anticancer Drugs In Vitro

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Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

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Assessing Specificity of Anticancer Drugs In Vitro

Assessing Specificity of Anticancer Drugs In Vitro

Published on: March 23, 2016

Conclusions:

Anticancer drug discovery requires a multi-pronged strategy.
Over-reliance on molecular targeting alone may hinder progress in developing new cancer treatments.