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Published on: July 21, 2023

Minimum inhibitory concentration of carbapenems and tigecycline against Salmonella spp

Malini R Capoor1, Deepthi Nair1, Jitendra Posti1

  • 1Department of Microbiology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

Journal of Medical Microbiology
|February 12, 2009
PubMed

Insights

Antimicrobial resistance in Salmonella is a major concern. Tigecycline and carbapenems show promise for treating multidrug-resistant Salmonella infections, including quinolone-resistant and ESBL-producing strains.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Antimicrobial resistance in Salmonella spp. poses a significant threat, particularly in quinolone-resistant and extended-spectrum beta-lactamase (ESBL)-producing strains.
  • These resistant strains can lead to complicated infections, necessitating the evaluation of alternative treatment options.

Purpose of the Study:

  • To determine the in vitro susceptibility of Salmonella spp. to various antimicrobial agents.
  • To evaluate the efficacy of tigecycline, carbapenems, and faropenem against multidrug-resistant Salmonella isolates.

Main Methods:

  • Minimum Inhibitory Concentrations (MICs) were determined for 210 Salmonella spp. isolates using E-test strips and agar dilution methods.
  • Antimicrobials tested included azithromycin, ciprofloxacin, cefixime, cefepime, ceftriaxone, gatifloxacin, imipenem, levofloxacin, meropenem, ofloxacin, tigecycline, and faropenem.

Main Results:

  • Carbapenems (imipenem, meropenem) exhibited a low MIC(90) of 0.064 µg/mL against Salmonella Typhi and Salmonella Paratyphi A.
  • Faropenem showed an MIC(90) of 0.25 µg/mL for S. Typhi, S. Paratyphi A, and Salmonella Typhimurium.
  • Tigecycline demonstrated MIC(90) values of 2 µg/mL for S. Typhi, 1 µg/mL for S. Paratyphi A, and 4 µg/mL for S. Typhimurium.

Conclusions:

  • Tigecycline and carbapenems are effective against quinolone-resistant and ESBL-producing multidrug-resistant Salmonella.
  • These agents are considered valuable options for the final stages of treatment for complicated Salmonella infections.

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