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Related Concept Videos

Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Shearing Stress01:18

Shearing Stress

Shearing stress, denoted by the Greek letter tau (τ), is stress caused by forces acting transversely on an object. These forces create internal ones within the entity in the plane where the external forces are applied. The resultant of these internal forces is the shear in the section.
The average shearing stress can be calculated by dividing the shear by the area of the cross-section.
Accessory Structures of the Skin: Hair and Hair Follicles01:16

Accessory Structures of the Skin: Hair and Hair Follicles

Hair and hair follicles are integral components of the integumentary system. Hair is a filamentous structure composed mainly of a protein called keratin. It is found on the surface of the skin throughout the body, except for areas such as the palms of the hands and soles of the feet.
Hair is a keratinous filament growing out of the epidermis. It is primarily made of dead, keratinized cells. Hair strands originate at the epidermal penetration called the hair follicle. The hair shaft is the part...
Pinching-off of Coated Vesicles01:32

Pinching-off of Coated Vesicles

Vesicle budding is orchestrated by distinct cytosolic proteins such as adaptor proteins, coat proteins, and GTPases. To initiate vesicle budding, membrane-bending proteins containing crescent-shaped BAR domains bind to the lipid heads in the bilayer and distort the membrane to form a protein-coated vesicle bud. Adaptors proteins such as AP2 for clathrin-coated vesicles can nucleate on the deformed membrane. Finally, coat proteins such as clathrin or COPI and COPII assemble into a coat forming...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Introduction to Plant Diversity02:22

Introduction to Plant Diversity

From Water to Land

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Clinical Examination Protocol to Detect Atypical and Classical Scrapie in Sheep
13:42

Clinical Examination Protocol to Detect Atypical and Classical Scrapie in Sheep

Published on: January 19, 2014

Woolly antics between the sheaths.

Desmond J Tobin1

  • 1Center for Skin Sciences, School of Life Sciences, University of Bradford, Bradford, West Yorkshire, UK. d.tobin@bradford.ac.uk

The Journal of Investigative Dermatology
|February 12, 2009
PubMed
Summary
This summary is machine-generated.

Researchers identified lipase H as a key factor influencing hair form and texture. This finding sheds light on the genetic controls behind diverse hair phenotypes, impacting appearance and well-being.

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Area of Science:

  • Genetics
  • Dermatology
  • Molecular Biology

Background:

  • Hair serves as a significant cultural signal, and perceived hair deficiencies can lead to psychological distress.
  • While hair follicle development and growth are well-studied, the genetic underpinnings of hair fiber form and texture remain largely unknown.
  • Significant variability exists in hair phenotypes even among closely related individuals.

Purpose of the Study:

  • To investigate the genetic factors controlling hair fiber form and texture.
  • To explore the potential role of lipase H in regulating hair characteristics.

Main Methods:

  • The study by Shimomura et al. investigated the function of lipase H.
  • Genetic and molecular analyses were employed to understand lipase H's mechanism of action.

Main Results:

  • Shimomura et al. present evidence suggesting lipase H plays a role in controlling hair form and texture.
  • The research provides novel insights into the molecular pathways influencing hair characteristics.

Conclusions:

  • Lipase H is a potential key regulator of hair form and texture.
  • Understanding these genetic controls could lead to new insights into hair biology and related conditions.