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Thyrotoxic periodic paralysis complicated with primary aldosteronism
1First Department of Internal Medicine, Miyazaki Medical College, Japan.
Japanese Journal of Medicine
|May 1, 1991
Summary
Hyperthyroidism triggers periodic paralysis in susceptible individuals. Primary aldosteronism exacerbates this risk, but treating hyperthyroidism prevents future attacks.
Area of Science:
- Endocrinology
- Neurology
Background:
- Periodic paralysis is a rare neuromuscular disorder characterized by episodes of muscle weakness.
- Thyrotoxicosis and primary aldosteronism are known risk factors for developing periodic paralysis.
Observation:
- A 35-year-old male presented with acute bilateral lower extremity weakness following high carbohydrate intake.
- Investigations revealed severe hypokalemia, hyperthyroidism, and primary aldosteronism due to an adrenal adenoma.
Findings:
- A glucose infusion test successfully induced hypokalemic paralysis, confirming the diagnosis.
- Treatment with methimazole resolved the periodic paralysis episodes, despite persistent primary aldosteronism.
Implications:
- Hyperthyroidism is a significant factor in the pathogenesis of periodic paralysis.
- Primary aldosteronism may increase susceptibility to paralytic attacks in individuals with underlying hyperthyroidism.