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Updated: Jun 25, 2026

An Integrated Approach for Microprotein Identification and Sequence Analysis
Published on: July 12, 2022
Unison: an integrated platform for computational biology discovery
1Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA. rkh@gene.com
Abstract:
This paper describes the design and applications of Unison, a comprehensive and integrated warehouse of protein sequences, diverse precomputed predictions, and other biological data. Unison provides a practical solution to the burden of preparing data for computational discovery projects, enables holistic feature-based mining queries regarding protein composition and functions, and provides a foundation for the development of new tools. Unison is available for immediate use online via direct database connections and a web interface. In addition, the database schema, command line tools, web interface, and non-proprietary precomputed predictions are released under the Academic Free License and available for download at http://unison-db.org/. This project has resulted in a system that significantly reduces several practical impediments to the initiation of computational biology discovery projects.
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