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Related Concept Videos

Obsessive-Compulsive Disorder01:28

Obsessive-Compulsive Disorder

Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...
Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
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Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
Personality Disorders: Dependent and Obsessive-Compulsive01:24

Personality Disorders: Dependent and Obsessive-Compulsive

Dependent personality disorder and obsessive-compulsive personality disorder are two separate psychological conditions that influence behavior, relationships, and overall life functioning. Though both involve maladaptive behaviors, their core characteristics and motivations differ significantly.
 Dependent Personality Disorder
Dependent personality disorder is characterized by an excessive reliance on others to manage various aspects of life. Individuals with this disorder often struggle with...

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Related Experiment Video

Updated: Jun 25, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

Neuroimaging in obsessive-compulsive disorder.

Jun Soo Kwon1, Joon Hwan Jang, Jung-Seok Choi

  • 1Department of Psychiatry, Seoul National University College of Medicine, 101 Daehak-no, Chongno-gu, Seoul, Korea 110-744. kwonjs@plaza.snu.ac.kr

Expert Review of Neurotherapeutics
|February 13, 2009
PubMed
Summary
This summary is machine-generated.

Neuroimaging studies reveal fronto-striato-thalamocortical circuit dysfunction in obsessive-compulsive disorder (OCD). This review updates findings on structural and functional brain imaging in OCD patients.

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Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
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Area of Science:

  • Neuroscience
  • Psychiatry

Background:

  • Obsessive-compulsive disorder (OCD) pathophysiology is increasingly understood through neuroimaging.
  • Current models highlight fronto-striato-thalamocortical circuitry dysfunction in OCD patients.

Purpose of the Study:

  • To review updated structural and functional neuroimaging findings in OCD.
  • To discuss limitations of traditional imaging techniques and recent advancements.

Main Methods:

  • Review of published structural and functional neuroimaging studies in OCD patients.
  • Analysis of findings from resting state and symptom provocation paradigms.

Main Results:

  • Consistent evidence of orbitofrontal cortex, anterior cingulate cortex, thalamus, and caudate nucleus dysfunction.
  • Reported dysfunctional activations in dorsolateral prefrontal cortex and parietal regions.
  • Emerging evidence suggests an imbalance between dorsal and ventral fronto-striatal circuits in OCD pathogenesis.

Conclusions:

  • Neuroimaging strongly implicates fronto-striato-thalamocortical circuit dysregulation in OCD.
  • Continued research utilizing advanced imaging techniques is crucial for understanding OCD pathophysiology.