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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Cross-reactivity00:42

Cross-reactivity

Overview

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Related Experiment Video

Updated: Jun 25, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
06:34

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

Micro-arrayed wheat seed and grass pollen allergens for component-resolved diagnosis.

C Constantin1, S Quirce, M Poorafshar

  • 1Division of Immunopathology, Department of Pathophysiology, Center of Physiology and Pathophysiology, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, Austria.

Allergy
|February 13, 2009
PubMed
Summary
This summary is machine-generated.

A new allergen micro-array can differentiate baker's asthma, wheat food allergy, and grass pollen allergy. Specific wheat and grass pollen allergens were identified for accurate diagnosis.

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Last Updated: Jun 25, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
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Published on: April 21, 2019

Area of Science:

  • Allergen immunotherapy
  • Immunological diagnostics
  • Wheat and grass pollen allergy research

Background:

  • Wheat is a significant source of allergens, causing baker's asthma, food allergies, and pollen allergies.
  • Accurate differential diagnosis is crucial for managing these distinct allergic conditions.

Purpose of the Study:

  • To develop an allergen micro-array for distinguishing between baker's asthma, wheat-induced food allergy, and grass pollen allergy.
  • To identify specific allergens for improved diagnostic accuracy.

Main Methods:

  • Analysis of immunoglobulin-E (IgE) reactivity profiles using micro-arrayed recombinant wheat flour and grass pollen allergens.
  • Comparison of micro-array results with clinical data and traditional diagnostic tests using crude allergen extracts.

Main Results:

  • Identified specific recombinant wheat flour allergens recognized by baker's asthma patients, distinct from those with wheat food allergy.
  • rPhl p 1 and rPhl p 5 identified as specific marker allergens for grass pollen allergy, potentially replacing grass pollen extracts.
  • Profilin identified as a cross-reactive allergen in all three conditions.

Conclusions:

  • Development of serological tests using micro-arrayed recombinant allergens is feasible for discriminating baker's asthma, wheat food allergy, and grass pollen allergy.
  • This approach offers a more precise diagnostic tool compared to conventional methods.