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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...

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Related Experiment Video

Updated: Jun 25, 2026

Characterization of Adipocyte-Derived Extracellular Vesicle Secretion Using a CD63-GFP Reporter Mouse Model In Vivo and In Vitro
10:40

Characterization of Adipocyte-Derived Extracellular Vesicle Secretion Using a CD63-GFP Reporter Mouse Model In Vivo and In Vitro

Published on: December 5, 2025

Obesity, adipokines and asthma.

T Jartti1, L Saarikoski, L Jartti

  • 1The Department of Pediatrics, Turku University Hospital, PO Box 52, FIN-20520 Turku, Finland.

Allergy
|February 13, 2009
PubMed
Summary

Obesity is linked to adult-onset asthma, but not childhood asthma. This study found no evidence that leptin or adiponectin explain the obesity-asthma connection in adults.

More Related Videos

Isolation of Adipose Tissue Immune Cells
07:09

Isolation of Adipose Tissue Immune Cells

Published on: May 22, 2013

Related Experiment Videos

Last Updated: Jun 25, 2026

Characterization of Adipocyte-Derived Extracellular Vesicle Secretion Using a CD63-GFP Reporter Mouse Model In Vivo and In Vitro
10:40

Characterization of Adipocyte-Derived Extracellular Vesicle Secretion Using a CD63-GFP Reporter Mouse Model In Vivo and In Vitro

Published on: December 5, 2025

Isolation of Adipose Tissue Immune Cells
07:09

Isolation of Adipose Tissue Immune Cells

Published on: May 22, 2013

Area of Science:

  • Epidemiology
  • Immunology
  • Public Health

Background:

  • Rising rates of asthma and obesity highlight the need to understand their complex relationship.
  • The specific role of immunomodulatory adipokines, such as leptin and adiponectin, in overweight-associated asthma remains unclear.

Purpose of the Study:

  • To investigate the association between obesity and asthma across three distinct life stages.
  • To determine if leptin and adiponectin levels correlate with asthma in the context of overweight and obesity.

Main Methods:

  • A prospective cohort study analyzed asthma and obesity associations at ages 3-18, 9-24, and 24-39 years.
  • Serum concentrations of leptin and adiponectin were measured and correlated with asthma status.
  • Additional data on allergy, smoking, insulin, C-reactive protein, and lipids were analyzed.

Main Results:

  • Allergy and parental asthma were significant predictors of asthma at all studied ages.
  • In adulthood (24-39 years), higher body mass index (BMI) and female gender were independently associated with asthma.
  • Increased BMI correlated with new-onset asthma during adulthood, but leptin, adiponectin, and other obesity biomarkers showed no independent association with asthma.

Conclusions:

  • Asthma is associated with obesity in adults, independent of other factors studied.
  • The immunomodulatory adipokines leptin and adiponectin, along with other studied obesity biomarkers, do not appear to mediate the link between obesity and asthma.
  • Further research is needed to elucidate the underlying mechanisms connecting obesity and asthma.