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Updated: Jun 25, 2026

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
Published on: March 7, 2019
The cholesterol side-chain cleavage complex in human brain white matter
C Goascogne1, M Gouézou, P Robel
1INSERM U 33, Communications Hormonales and Faculté de Médicine, Université Paris-Sud, F-94275 Bicêtre Cedex, France.
Abstract:
Abstract Specific antibodies obtained in rabbits after injection of bovine cholesterol side-chain cleavage enzymes cytochrome P-450scc, adrenodoxin and adrenodoxin-reductase were used for immunohistochemical studies in human brain. The three enzymes were co-localized in the white matter of the cerebellum. This observation strongly suggests the existence of steroidogenic activity in human oligodendrocytes, as previously reported in the rat, and suggests that the concept of 'neurosteroids' can be applied to Delta5-3ss-hydroxysteroid metabolites of cholesterol that accumulate in human brain.
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