Related Experiment Video
Updated: Jun 25, 2026
08:57
Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
Published on: May 17, 2024
Histologic mimics of perineural invasion
Martin Dunn1, Michael B Morgan, Trevor W Beer
1Skin Cancer Specialist, Inc., Sarasota, FL 34233, USA. mjdunnmd@hotmail.com
Journal of Cutaneous Pathology
|February 13, 2009
Summary
Microscopic perineural invasion (PNI) in skin cancers can be mimicked by benign conditions. Identifying these four mimics is crucial for accurate diagnosis and avoiding unnecessary treatments.
Area of Science:
- Dermatopathology
- Surgical Oncology
Background:
- Perineural invasion (PNI) is a significant adverse risk factor in primary cutaneous cancers.
- Benign conditions can mimic microscopic PNI, posing diagnostic challenges.
- Mohs surgery for small skin cancers may involve microscopic PNI in a single nerve branch.
Purpose of the Study:
- To identify benign entities that mimic microscopic perineural invasion (PNI).
- To aid dermatopathologists in distinguishing benign mimics from actual PNI.
Main Methods:
- Literature review on perineural invasion (PNI).
- Presentation of original findings and case studies.
Main Results:
- Four specific benign conditions were identified as potential mimics of microscopic PNI.
- These entities can be easily confused with actual perineural invasion.
Conclusions:
- At least four benign mimics of microscopic PNI exist.
- Correctly distinguishing these mimics from PNI is vital for appropriate patient management.
- Knowledge of these mimics helps prevent unnecessary treatments for skin cancer patients.
