Related Experiment Video
Updated: Jun 25, 2026
Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
Published on: May 17, 2024
Histologic mimics of perineural invasion
Martin Dunn1, Michael B Morgan, Trevor W Beer
1Skin Cancer Specialist, Inc., Sarasota, FL 34233, USA. mjdunnmd@hotmail.com
Background:
Perineural invasion (PNI) by primary cutaneous cancers is an important adverse risk factor. Certain benign conditions may mimic microscopic PNI. Mohs surgery is being performed more frequently on smaller primary cutaneous malignancies. While PNI may be present in these cases, it is likely to be microscopic and asymptomatic, affecting as little as one cutaneous nerve branch.
Methods:
Review of the literature base regarding PNI as well as contribution of original findings.
Results:
Four benign entities that could easily be confused with microscopic PNI are presented.
Conclusion:
At least four benign mimics of microscopic PNI exist, important in the differential diagnosis of microscopic PNI. Knowledge of these entities should help dermatopathologists to correctly distinguish them from PNI and avoid unnecessary additional treatment.
