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The feasibility and reliability of using circular electrode for sphincter of Oddi electromyography in anaesthetised
1Hepatobiliary Surgery Institute, Southwest Hospital, Third Military Medical University, Chongqing, PR China.
Abstract:
Sphincter of Oddi manometry (SOM) is the gold standard for assessing sphincter of Oddi dysfunction (SOD), but is considered a diagnostic sensitivity of 30-80% and associated with significant complications of pancreatitis. Electromyography (EMG) of sphincter of Oddi (SO) using a circular electrode (CE) may be useful in improving diagnostic accuracy and reducing complications. To evaluate the feasibility and reliability of the CE, we record myoelectric activity of SO in rabbits using the CE to compare with the traditional needle electrode (NE). The CE was prepared using a double-channel biogel catheter with two silver rings at the head of the catheter. The CE was then inserted into the lumen of the SO through the duodenal papilla, and myoelectric activity was recorded in the SO in 30 rabbits. An EMG recorded using an NE was performed at the same time, when the SO was in basal state, after injection of cholecystokinin and N-butylscopolamine bromide. Electromyographs recorded by the two methods were then evaluated. Satisfactory SO EMGs were acquired using the CE without any injury. Simultaneous recording revealed a very similar traces and one-to-one correspondence of SO spike bursts (SOSB). Linear regression analysis showed a significant direct correlation between the two methods for SOSB duration and amplitude. The results suggested that CE was comparable with NE in terms of recording efficacy. The CE also has advantages of easy fixation, accurate localisation, broad applicability and ease of achieving satisfactory outcomes without trauma, compared with the NE.
Insights
A new circular electrode (CE) for sphincter of Oddi (SO) electromyography (EMG) shows comparable efficacy to traditional needle electrodes (NE). This CE method offers improved safety and accuracy for diagnosing sphincter of Oddi dysfunction (SOD).
Area of Science:
- Gastroenterology
- Medical Devices
- Surgical Technology
Background:
- Sphincter of Oddi manometry (SOM) is the gold standard for diagnosing sphincter of Oddi dysfunction (SOD) but has low sensitivity (30-80%) and risks pancreatitis.
- Electromyography (EMG) of the sphincter of Oddi (SO) using a circular electrode (CE) may offer improved diagnostic accuracy and reduced complications compared to needle electrodes (NE).
Purpose of the Study:
- To evaluate the feasibility and reliability of a novel circular electrode (CE) for recording SO myoelectric activity.
- To compare the efficacy of CE-based SO EMG with traditional needle electrode (NE) recordings in rabbits.
Main Methods:
- A double-channel biogel catheter with a CE was developed and inserted into the SO lumen via the duodenal papilla in 30 rabbits.
- Simultaneous SO EMG recordings were obtained using both CE and NE under basal conditions and after cholecystokinin and N-butylscopolamine bromide administration.
- Myoelectric activity, including SO spike bursts (SOSB) duration and amplitude, was analyzed and compared between the two methods.
Main Results:
- Satisfactory SO EMGs were acquired using the CE without causing injury.
- CE and NE recordings demonstrated highly similar traces and a one-to-one correspondence of SOSB.
- Linear regression revealed a significant positive correlation between CE and NE for SOSB duration and amplitude.
Conclusions:
- The CE is a feasible and reliable tool for SO EMG, comparable in efficacy to the NE.
- The CE offers advantages including easy fixation, accurate localization, broad applicability, and atraumatic outcomes.
- CE-based SO EMG presents a promising alternative for diagnosing SOD with potentially enhanced safety and diagnostic precision.
