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Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients
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Published on: March 1, 2024

Secondary syphilis presenting as SAPHO syndrome features.

Y Arnson1, A Rubinow, H Amital

  • 1Meir Medical Center, Kefar Saba Israel, affiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Clinical and Experimental Rheumatology
|February 13, 2009
PubMed
Summary

Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) syndrome can develop after infections. A syphilis infection was linked to SAPHO syndrome in a patient whose symptoms improved with antibiotics.

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Area of Science:

  • Rheumatology
  • Infectious Diseases
  • Dermatology

Background:

  • Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) syndrome is a rare autoinflammatory disorder.
  • The etiology of SAPHO syndrome is not fully understood, but infections are suspected triggers.
  • Low-virulence infections have been implicated in the development of SAPHO syndrome.

Observation:

  • This case report details a patient who presented with SAPHO syndrome following an infection with syphilis.
  • The patient's clinical manifestations met the diagnostic criteria for SAPHO syndrome.
  • The patient's symptoms showed gradual improvement after initiating antibiotic treatment.

Findings:

  • A direct correlation between Treponema pallidum infection and the induction of SAPHO syndrome is suggested.
  • The resolution of SAPHO symptoms following antibiotic therapy indicates a potential link between bacterial infection and the syndrome.
  • The exact mechanism, whether bacterial eradication or cessation of an autoinflammatory response, requires further investigation.

Implications:

  • This case highlights the importance of considering infectious triggers, such as syphilis, in patients with SAPHO syndrome.
  • Understanding the link between infections and rheumatic conditions like SAPHO syndrome can improve diagnostic and therapeutic approaches.
  • Further research is warranted to elucidate the pathogenic pathways connecting Treponema pallidum infection and SAPHO syndrome.