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A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

[Risk factors of the hepatic dysfunction associated with parenteral nutrition]

Luis Servia1, Joan Antonio Schoenenberger, Javier Trujillano

  • 1Servicio de Medicina Intensiva, Hospital Universitario Arnau de Vilanova, Lleida, España. lservia@telefonica.net

Medicina Clinica
|February 13, 2009
PubMed

Insights

Prolonged parenteral nutrition (PN) increases the risk of hepatic dysfunction (HD) in critical patients. Monitoring protein intake is crucial for patients receiving long-term PN to prevent HD development.

Area of Science:

  • Clinical Nutrition
  • Gastroenterology
  • Patient Safety

Context:

  • Parenteral nutrition (PN) is essential for patients unable to receive enteral feeding.
  • Hepatic dysfunction (HD) is a potential complication of PN.
  • Identifying risk factors for HD is crucial for improving patient care.

Purpose:

  • To determine the incidence of hepatic dysfunction (HD) in patients receiving parenteral nutrition (PN).
  • To identify risk factors associated with the development of HD in this patient population.
  • To inform strategies for improving patient care during PN therapy.

Summary:

  • A prospective study of 994 patients requiring PN identified an HD incidence of 4.9%.
  • Independent risk factors for HD included prolonged PN (>3 weeks), critical patient status, and high nitrogen intake (>0.16g/kg).
  • Patients with HD received PN for significantly longer durations compared to those without HD.

Impact:

  • Findings highlight the need for vigilant monitoring of liver function in patients undergoing prolonged PN.
  • Results emphasize the importance of optimizing protein administration in critically ill patients receiving PN.
  • This study provides evidence to refine clinical protocols for PN management and reduce HD incidence.
Abstract

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