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Ventricular dysfunction and number of non compacted segments in non compaction: non-independent predictors

Giovanni Fazio1, Giovanni Corrado, Giuseppina Novo

  • 1Department of Cardiology, University of Palermo, Italy.

International Journal of Cardiology
|February 13, 2009
PubMed

Insights

Isolated ventricular noncompaction (IVNC) involves deep recesses and trabeculations, potentially leading to heart failure. This study found no correlation between the number of affected segments and the severity of systolic dysfunction in IVNC patients.

Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Cardiac Morphology

Background:

  • Isolated ventricular noncompaction (IVNC) is a congenital heart defect characterized by excessive trabeculations and deep intertrabecular recesses.
  • Chronic heart failure affects approximately half of IVNC patients, highlighting the need to understand factors influencing cardiac function.

Purpose of the Study:

  • To investigate the correlation between the extent of non-compacted segments and the degree of systolic dysfunction in patients with IVNC.
  • To determine if the number of affected segments predicts left ventricular systolic dysfunction.

Main Methods:

  • A consecutive series of 238 IVNC patients from the SIEC registry were evaluated.
  • Ventricular structure, systolic function (ejection fraction), and diastolic dysfunction were assessed.
  • Statistical analysis was performed to identify predictors of left ventricular systolic dysfunction.

Main Results:

  • 122 patients (51.3%) exhibited ventricular systolic dysfunction with an average ejection fraction of 34.6%.
  • The number of non-compacted segments and the presence of diastolic dysfunction were identified as non-independent predictors of LV systolic dysfunction.
  • However, further analysis indicated that ventricular dysfunction appears independent of the number of non-compacted segments.

Conclusions:

  • Ventricular dysfunction in isolated ventricular noncompaction may not be directly correlated with the number of affected segments.
  • Further research is needed to fully elucidate the relationship between non-compaction extent and cardiac dysfunction severity.
Abstract

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