Related Experiment Video
Updated: Jun 25, 2026
13:22
Kinase Inhibitor Screening In Self-assembled Human Protein Microarrays
Published on: October 23, 2019
N-substituted 2'-(aminoaryl)benzothiazoles as kinase inhibitors: hit identification and scaffold hopping
Stefan Tasler1, Oliver Müller, Tanja Wieber
14SC AG, Am Klopferspitz 19a, 82152 Planegg-Martinsried, Germany.
Bioorganic & Medicinal Chemistry Letters
|February 13, 2009
Abstract:
Starting with a hit from vHTS attained by a docking procedure of virtual compounds into ATP pockets of different kinases applying the 4SCan technology, variations of the adenine mimic resulted in the identification of promising scaffolds, giving rise to in vitro IC(50) values in the nanomolar range on different kinases down to 63nM.
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