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Updated: Jun 25, 2026

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
Published on: March 2, 2014
Antiviral defense: RIG-Ing the immune system to STING
J Bradford Bowzard1, Priya Ranjan, Suryaprakash Sambhara
1Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Abstract:
A critical component of the innate immune response is the presence of germ line-encoded receptors capable of recognizing a wide variety of pathogen-associated molecules. One group of these receptors, the cytoplasmic RIG-I-like helicases (RLH), is involved in the induction of Type I interferon in response to viral infection. Here we discuss results of recent investigations into the initiation and transmission of signals through the RIG-I pathway.
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