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Updated: Jun 25, 2026
A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
[Fundamental and translational research on hepatocellular carcinoma in 2008: forces and priorities]
J Zucman-Rossi1, B Clément, M-A Buendia
1Inserm, U674 ; université Paris-Diderot-Paris-VII, 75010 Paris, France. zucman@cephb.fr
Abstract:
Hepatocellular carcinogenesis is usually the result of a muti-step process. It begins with an exposure to various risk factors; followed by the development of a chronic hepatitis and cirrhosis that is a pre-neoplastic step; and finally after the occurrence of an hepatocellular carcinoma (HCC), different molecular events control aggressiveness of the tumors. The aim of this work was to identify in the international context, forces and priorities of the fundamental and translational HCC research.
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