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Updated: Jun 25, 2026

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
Published on: October 27, 2014
Targeting the tumour stroma to increase efficacy of chemo- and radiotherapy
1Institute for Cell Biology, Department of Molecular Cell Biology, University of Duisburg-Essen, Essen, Germany.
Abstract:
The impact of a favourable microenvironment on tumour progression is a limiting factor for current tumour therapy protocols, as it contributes to the selection of resistant tumour cells. Apart from immune and inflammatory cells, the extracellular matrix, cancer-associated fibroblasts and vascular endothelial cells are crucial mediators of protective signals. An important research effort exposes potential environmental targets that may define new therapeutic strategies for solid tumours.
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