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Related Experiment Video

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The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

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Published on: May 31, 2016

Hot flashes and fatigue relieved by metformin.

Vinay Maudar¹, Stephen J Winters, Betty C Villafuerte

¹Department of Medicine, Division of Endocrinology and Metabolism, University of Louisville School of Medicine, Louisville, Kentucky, USA.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

|February 13, 2009

Summary

Metformin effectively treated hot flashes, sweating, and fatigue in three patients with hyperinsulinemia. This suggests metformin may help manage symptoms linked to this endocrine condition.

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Area of Science:

Endocrinology
Metabolic Disorders

Background:

Hot flashes, excessive sweating, and fatigue are common symptoms that can significantly impact quality of life.
Endocrine dysfunction can manifest with a variety of nonspecific symptoms, necessitating thorough evaluation.

Observation:

Three patients presented with long-standing symptoms of hot flashes, excessive sweating, and fatigue.
Initial laboratory evaluations, including endocrine assessments and oral glucose tolerance tests, did not reveal a definitive cause for their symptoms.

Findings:

All three patients exhibited hyperinsulinemia despite normal glucose tolerance test results.
Treatment with metformin (500 mg twice daily) resulted in marked symptom relief for all patients.

Implications:

Hyperinsulinemia, even without hypoglycemia, may trigger a sympathoexcitatory response causing symptoms like hot flashes and sweating.
Metformin's potential sympathoinhibitory actions could offer a therapeutic avenue for managing these symptoms in patients with hyperinsulinemia.