Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 25, 2026

In Vivo Visualization of Spontaneous Activity in Neonatal Mouse Sensory Cortex at a Single-Neuron Resolution
06:18

In Vivo Visualization of Spontaneous Activity in Neonatal Mouse Sensory Cortex at a Single-Neuron Resolution

Published on: November 21, 2023

Relationship between spontaneous and evoked spike-time correlations in primate visual cortex.

Walter J Jermakowicz1, Xin Chen, Ilya Khaytin

  • 1Dept. of Cell and Developmental Biology,Vanderbilt Medical School, U3218 Learned Lab, Nashville, TN 37232, USA.

Journal of Neurophysiology
|February 13, 2009
PubMed
Summary

Spike-time correlations in the visual cortex are not solely driven by visual stimuli. These neural synchronies appear to originate from intrinsic cortical activity, even during spontaneous conditions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Computer-aided diagnostic screen for Congenital Central Hypoventilation Syndrome with facial phenotype.

Pediatric research·2024
Same author

Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation (ROHHAD): a collaborative review of the current understanding.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2023
Same author

Ventilatory and Orthostatic Challenges Reveal Biomarkers for Neurocognition in Children and Young Adults With Congenital Central Hypoventilation Syndrome.

Chest·2023
Same author

Transitional care and clinical management of adolescents, young adults, and suspected new adult patients with congenital central hypoventilation syndrome.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2022
Same author

Neurocognition as a biomarker in the rare autonomic disorders of CCHS and ROHHAD.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2022
Same author

Evolution of physiologic and autonomic phenotype in rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation over a decade from age at diagnosis.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine·2021

Area of Science:

  • Neuroscience
  • Visual Neuroscience
  • Computational Neuroscience

Background:

  • Coincident spikes are crucial for visual processing, including feature binding and communication.
  • The origins of spike-time correlations in the visual cortex remain unclear.
  • Existing theories propose stimulus-driven or spontaneous activity as sources.

Purpose of the Study:

  • To investigate whether spike-time correlations in primary visual cortex (V1) are stimulus-dependent or reflect ongoing spontaneous activity.
  • To compare neural synchrony patterns under different visual stimulation conditions.

Main Methods:

  • Recorded single-unit activity from the primary visual cortex (V1) of anesthetized bush babies using a 100-electrode array.
  • Analyzed spike-time correlations using cross-correlation histograms (CCHs).

More Related Videos

Stimulus-specific Cortical Visual Evoked Potential Morphological Patterns
09:42

Stimulus-specific Cortical Visual Evoked Potential Morphological Patterns

Published on: May 12, 2019

Related Experiment Videos

Last Updated: Jun 25, 2026

In Vivo Visualization of Spontaneous Activity in Neonatal Mouse Sensory Cortex at a Single-Neuron Resolution
06:18

In Vivo Visualization of Spontaneous Activity in Neonatal Mouse Sensory Cortex at a Single-Neuron Resolution

Published on: November 21, 2023

Stimulus-specific Cortical Visual Evoked Potential Morphological Patterns
09:42

Stimulus-specific Cortical Visual Evoked Potential Morphological Patterns

Published on: May 12, 2019

  • Compared CCHs under three conditions: moving grating, blank screen, and dark condition.

    • Main Results:

    • Spike-time correlations showed strong similarities across all tested conditions.
    • CCHs were broader and had lower peak amplitudes in blank and dark conditions compared to stimulus-evoked activity.
    • Correlation amplitudes increased for cell pairs with overlapping receptive fields and similar orientation preferences.

    Conclusions:

    • Spike-time correlations observed during evoked activity likely stem from the same mechanisms underlying spontaneous neural activity.
    • Intrinsic cortical processes, rather than external stimuli alone, significantly shape neural synchrony in V1.