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[Results of specific hyposensitization in children with pollinosis]
R Schuster1, A Quassem, V Sollich
1Klinik für Kinderheikunde, Medizinischen Akademie Magdeburg.
Insights
Pollen immunotherapy (hyposensitization) in children achieved a 70.8% success rate, with outcomes influenced by disease duration and treatment length. Early intervention is recommended for optimal results in managing hay fever and allergic asthma.
Area of Science:
- Allergy and Immunology
- Pediatric Pulmonology
Context:
- Pollen allergy significantly impacts children's quality of life.
- Hyposensitization is a long-term treatment option for allergic rhinitis and asthma.
Purpose:
- To evaluate the efficacy and outcomes of pollen hyposensitization in pediatric patients.
- To identify factors influencing treatment success and adverse events.
Summary:
- A retrospective study analyzed 120 children (5-15 years) undergoing 3-5 years of pollen hyposensitization.
- Treatment involved mixed pollen or grass pollen allergens, with success rates of 70.8%.
- Factors like disease duration, treatment length, and asthma comorbidity affected outcomes. Local and systemic side effects were noted.
Impact:
- Hyposensitization demonstrates significant success in managing pediatric pollen allergies.
- Early and accurate indication for immunotherapy is crucial for better patient outcomes.
- Understanding influencing factors can optimize treatment strategies for allergic diseases in children.
Abstract:
Hyposensitization was carried out in 120 children aged 5 to 15 years with proven sensitivity to various pollen for 3 to 5 years before the start of the season. By reason of the results of intracutaneous tests 90 patients were treated with mixed pollen allergen and 30 patients with grass pollen allergen. A retrospective study was undertaken on the base of a questionnaire. Every year after the season duration and severity of symptoms as well as consumption of medicine were registered. The total success of hyposensitization amounted to 70.8% and this result varied on the one hand in dependence of the duration of disease on the other hand in dependence of the duration of treatment. A more inconvenient result was seen in those children who suffered from asthmatic symptoms exclusively compared to patients with hay fever. Local side effects resulted sporadically in 71.5% and systemic side effects in 15.7% by subcutaneous injection of depot-pollen allergen. Despite of extensive and not indifferent mode of treatment, hyposensitization should be performed in a correct way as soon as possible after exact indication.