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Updated: Jun 25, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
[A rare pulmonary tumour, primary malignant melanoma]
P Saint-Blancard1, F Vaylet, R Jancovici
1Service d'Anatomie et de cytologie pathologiques, Hôpital d'Instruction des Armées Percy, Clamart, France. psbpercy@yahoo.fr
Introduction:
Malignant melanoma most commonly presents as a primary neoplasm of the skin, but has been described in other mucosal sites. Rarely, malignant melanomas have been reported as primary visceral neoplasms, including the lung. Most such lesions have been dismissed as metastases from undocumented or regressed primary cutaneous or ocular melanomas.
Case Report:
We report an original observation of an 82-year-old man with a pulmonary nodule presenting with chest pain. The diagnosis of melanoma was established on biopsies carried out under computerized tomography scanning and confirmed after right upper lobectomy two months later.
Discussion:
Melanomas of the respiratory tract are usually metastatic in origin and a primary melanoma in very rare. Strict criteria must be applied before a diagnosis of primary malignant melanoma of lower respiratory tract can be accepted. Melanoma may be confused with more conventional types of lung cancer and other pigmented tumours.
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