Molecular differentiation and specialization of vascular beds

Transport in the large and complex bodies of vertebrate organisms is mediated by extensive and highly branched tubular networks that are formed by endothelial cells. Blood vessels are responsible for systemic circulation, while the lymphatic vasculature drains extravasated plasma, proteins, particles, and cells from the interstitium. Endothelial cells of blood vessels and lymphatic vessels can be distinguished by the expression of certain molecular markers, which accompany or even contribute to functional and morphological differences. Even within the blood vessel network, some molecules and pathways selectively mark the endothelium of arteries, veins and capillaries and are thought to contribute to the differentiation of these vessels. Moreover, microvessels can acquire organ-specific specialization in response to local tissue-derived signals. This review summarizes molecular markers and pathways that are specifically expressed in the endothelium of certain vascular beds and vessel types. Special attention will be given to known functional roles in the morphogenesis of these vessels.