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Updated: Jun 25, 2026

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade

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Published on: March 14, 2011

[Allogeneic hematopoietic stem cell transplantation].

Mohamad Mohty¹

¹Service d'hématologie, centre de recherche en cancérologie de Nantes-Angers, Inserm U892, hôpital Hôtel-Dieu, CHU de Nantes, 44093 Nantes Cedex, France. mohamad.mohty@univ-nantes.fr

La Revue Du Praticien

|February 14, 2009

Summary

This summary is machine-generated.

Allogeneic hematopoietic stem cell transplantation offers a cure for hematologic malignancies through a graft-versus-leukemia effect. While graft-versus-host disease is a complication, this therapy is expanding due to its demonstrated anti-tumor impact.

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Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade

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Isolation and Transplantation of Hematopoietic Stem Cells (HSCs)

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Published on: February 25, 2007

Area of Science:

Hematology
Immunology
Oncology

Context:

Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative treatment for hematologic malignancies.
The primary anti-tumor mechanism is the graft-versus-leukemia (GVL) effect mediated by donor immune cells.
Various donor types, stem cell sources, and preparative regimens (myeloablative and immunosuppressive) are utilized.

Purpose:

To review the principles, applications, and challenges of allogeneic HSCT in treating hematologic cancers.
To highlight the balance between the therapeutic GVL effect and the risks of graft-versus-host disease (GVHD).

Summary:

Allogeneic HSCT leverages donor immune cells to eliminate cancer cells (GVL effect), offering a cure for various leukemias and lymphomas.
Graft-versus-host disease (GVHD) remains a significant complication, necessitating immunosuppression and increasing infection risk.
Despite GVHD, HSCT is expanding due to its proven efficacy in both myeloid and lymphoid malignancies with manageable toxicity.

Impact:

Allogeneic HSCT provides a vital curative strategy for patients with hematologic malignancies.
Understanding and mitigating GVHD is crucial for improving long-term outcomes and patient survival.
The expanding application of HSCT underscores its critical role in modern cancer therapy.