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Published on: July 31, 2016
Phase II trial of carboplatin and paclitaxel in papillary renal cell carcinoma
Kathryn A Bylow1, Michael B Atkins, Edwin M Posadas
1Department of Medicine, Section of Hematology/Oncology, University of Chicago, IL, USA. kbylow@mcw.edu
Background:
Cytotoxic chemotherapy has not been well investigated in non-clear-cell renal cell carcinoma (RCC). A phase II study was thus conducted to assess the efficacy of carboplatin and paclitaxel in such patients.
Patients And Methods:
Patients were treated with carboplatin (area under the curve of 6) and paclitaxel 225 mg/m2 every 21 days and assessed for measurable disease response every 2 cycles. An initial 20 patients were planned to be enrolled to rule out a null hypothesized 15% response rate.
Results:
Seventeen patients were enrolled, of which 16 patients had papillary and 1 had collecting duct histology. The patient with collecting duct histology had a complete response, but no responses were observed in patients with papillary histology and the trial was thus terminated early. Toxicities were as expected for the carboplatin and paclitaxel regimen.
Conclusion:
Carboplatin and paclitaxel is not an active regimen in patients with metastatic papillary RCC. Future studies should explore the role of this or similar regimens in collecting duct carcinoma.
