Related Experiment Video
Updated: Jun 25, 2026
06:38
Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
Published on: March 11, 2016
Antenatal detection of renal malformations
Abhijeet Saha1, Prerna Batra, Pushpa Chaturvedi
1Pediatric Renal Unit, Department of Pediatrics, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha, Maharashtra, India. drabhijeetsaha@yahoo.com
Indian Pediatrics
|February 14, 2009
Summary
Antenatal screening detected renal malformations in 35 fetuses, with 27 confirmed postnatally. This study highlights the utility of prenatal screening for early diagnosis of congenital kidney anomalies.
Area of Science:
- Pediatrics
- Obstetrics
- Urology
Background:
- Congenital renal malformations are a significant cause of pediatric morbidity.
- Early detection through antenatal screening can improve outcomes.
- Data on the incidence and outcomes of antenatal renal malformations in rural settings are limited.
Purpose of the Study:
- To determine the incidence and outcomes of antenatally detected renal malformations in rural Maharashtra.
- To evaluate the effectiveness of antenatal screening for renal anomalies.
Main Methods:
- Prospective study involving 7365 deliveries.
- Antenatal screening for renal malformations performed on 6682 deliveries (90.7%).
- Postnatal investigations to confirm antenatal findings.
Main Results:
- Renal malformations were detected in 35 fetuses.
- Postnatal confirmation in 27 babies, yielding an incidence of 0.4% among liveborns.
- Surgical intervention was required for 7 babies, with 2 awaiting surgery; 4 patients had poor outcomes (2 expired, 2 lost to follow-up).
Conclusions:
- Antenatal screening is a valuable tool for diagnosing fetal renal malformations.
- Early detection allows for timely intervention and management planning.
- The incidence of antenatally detected renal malformations in this rural population was 0.4%.
Related Concept Videos
01:07Teratogenicity
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
01:26Nursing Assessment of the Genitourinary System II: Inspection and Palpation
The nursing assessment of the genitourinary (GU) system involves a systematic inspection and palpation to identify abnormalities in the kidneys, bladder, and surrounding structures.InspectionMouth: Inspect for signs of kidney dysfunction, such as stomatitis (inflammation of the mouth) and ammonia breath, which may occur in advanced kidney disease due to the buildup of urea, breaking down into ammonia.Skin: Check for pallor, which could indicate anemia caused by kidney disease. Look for...
01:24Imaging Studies II: Ultrasonography
IntroductionUltrasonography, or renal ultrasound, is a noninvasive medical imaging technique that uses high-frequency sound waves to visualize the kidneys, ureters, bladder, and surrounding tissues.Indications for Urinary System UltrasonographyUrinary system ultrasonography is indicated in various clinical scenarios, such as:Kidney Stones (Urolithiasis): To detect and monitor the size and presence of kidney or urinary tract stones.Hydronephrosis: To assess the dilation of the renal pelvis and...
01:19Imaging Studies VII: Vascular Imaging
DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
01:27Imaging Studies IV: Magnetic Resonance Imaging
Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...