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In Vitro Imaging and Quantification of the Drug Targeting Efficiency of Fluorescently Labeled GnRH Analogues
Published on: March 21, 2017
Prodrugs of thyrotropin-releasing hormone and related peptides as central nervous system agents
Katalin Prokai-Tatrai1, Laszlo Prokai
1Department of Pharmacology & Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA. kprokai@hsc.unt.edu
Abstract:
Prodrug design for brain delivery of small- and medium-sized neuropeptides was reviewed, focusing on thyrotropin-releasing hormone and structurally related peptides as examples. We have summarized our most important advances in methodology, as well as assessed the benefits and limitations of bioreversible chemical manipulation techniques to achieve targeting of the parent molecules into the central nervous system. The value of prodrug-amenable analogues as potential drug-like central nervous systems agents was highlighted.
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