All that bleeds is not infliximab-refractory ulcerative colitis
1Division of Gastroenterology, University of British Columbia, and Gastroenterology Clinic, St Paul's Hospital, Vancouver, British Columbia, Canada. jklaw99@gmail.com
Summary
Infliximab may induce remission in severe ulcerative colitis but carries risks. This case highlights potential complications like lower gastrointestinal hemorrhage after initial treatment success.
Area of Science:
- Gastroenterology
- Immunology
Background:
- Biological agents are effective for moderate to severe ulcerative colitis remission.
- The efficacy of infliximab for fulminant colitis induction is debated.
Observation:
- A patient with severe ulcerative colitis refractory to steroids was treated with infliximab.
- The patient achieved clinical remission and was discharged.
Findings:
- The patient later presented with lower gastrointestinal hemorrhage.
- This suggests potential risks associated with infliximab therapy in severe cases.
Implications:
- Further research is needed on infliximab's safety profile in fulminant colitis.
- Careful monitoring is crucial for patients treated with infliximab for severe ulcerative colitis.
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