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Endocrine cells in ampullary carcinoma
Terumi Kamisawa1, Yuyang Tu, Naoto Egawa
1Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo, 113-8677, Japan. kamisawa@cick.jp
Journal of Hepato-Biliary-Pancreatic Surgery
|February 14, 2009
Summary
Ampullary carcinoma with endocrine cells appears less aggressive, originating from the ampullopancreaticobiliary duct or ampulloduodenum. This finding impacts understanding of ampullary carcinoma behavior and origin.
Area of Science:
- Gastroenterology
- Surgical Pathology
- Oncology
Background:
- Ampullary carcinoma arises from diverse anatomical origins, potentially influencing its clinical behavior.
- The presence and implications of endocrine cells within ampullary carcinoma require further investigation.
Purpose of the Study:
- To document the presence of endocrine cells in ampullary carcinoma.
- To investigate the clinicopathological significance of endocrine cell presence in ampullary carcinoma.
Main Methods:
- Immunohistochemical analysis of 62 surgically resected ampullary carcinoma specimens.
- Comparison of clinicopathological features between endocrine component-positive and -negative ampullary carcinoma cases.
Main Results:
- Endocrine cells were detected in 26% of cases, with serotonin positivity in all instances.
- Endocrine component-positive ampullary carcinomas showed less frequent pancreatic invasion and lymph node involvement (P < 0.01).
- Histology was predominantly intestinal type; no significant differences in CA 19.9, CEA, p53, or K-ras were observed.
Conclusions:
- Endocrine component-positive ampullary carcinoma likely originates from the ampullopancreaticobiliary common duct or ampulloduodenum.
- This subtype appears to exhibit less aggressive behavior compared to endocrine component-negative ampullary carcinoma.
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