Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

MAPK/ERK signaling regulates H3K9me3 heterochromatin reorganization to confer mesendoderm developmental competence.

Nucleic acids research·2026

Same author

Automated Segmentation of Diffuse and Multifocal Nerve Enlargement in Immune-Mediated Neuropathy Using Temporal Deep Learning on Continuous Ultrasound Scans.

Diagnostics (Basel, Switzerland)·2026

Same author

Intercostal artery embolization and the risk of spinal cord ischemia: Importance of identifying the Adamkiewicz artery-A report of two cases.

Radiology case reports·2026

Same author

Metacognition that a cognitive task disrupts subsequent recognition causes the revelation effect.

Acta psychologica·2026

Same author

Dynamic regulation of H3K9 dimethylation drives mouse minor zygotic genome activation.

Nature structural & molecular biology·2026

Same author

Idiopathic pulmonary fibrosis predicts local recurrence following surgery in patients with non-small cell lung cancer.

Journal of cancer research and clinical oncology·2026

Search research articles

Related Experiment Video

Updated: Jun 25, 2026

Thoracoscopic Extended Right Middle Plus Lower Sleeve Lobectomy for Non-Small-Cell Lung Cancer

Thoracoscopic Extended Right Middle Plus Lower Sleeve Lobectomy for Non-Small-Cell Lung Cancer

Published on: February 27, 2026

Biphasic pulmonary blastoma with rapid progression.

Ryo Maeda¹, Noritaka Isowa, Hideyuki Onuma

¹Division of Thoracic Surgery, Matsue Red Cross Hospital, 200 Horomachi, Matsue, Shimane 690-8506, Japan. ryomaedamatsue@yahoo.co.jp

General Thoracic and Cardiovascular Surgery

|February 14, 2009

Summary

This case study details a rare biphasic pulmonary blastoma (BPB) in an elderly man, highlighting its aggressive nature and rapid progression. Early detection and surgical intervention were insufficient to prevent recurrence and eventual mortality.

More Related Videos

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma (DIPG)

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma (DIPG)

Published on: March 7, 2017

Related Experiment Videos

Last Updated: Jun 25, 2026

Thoracoscopic Extended Right Middle Plus Lower Sleeve Lobectomy for Non-Small-Cell Lung Cancer

Thoracoscopic Extended Right Middle Plus Lower Sleeve Lobectomy for Non-Small-Cell Lung Cancer

Published on: February 27, 2026

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma (DIPG)

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma (DIPG)

Published on: March 7, 2017

Area of Science:

Pulmonology
Oncology
Pathology

Background:

Biphasic pulmonary blastoma (BPB) is an exceptionally rare primary lung malignancy.
This tumor type exhibits aggressive behavior and a propensity for rapid progression.

Observation:

A 75-year-old male presented with a large, well-defined tumor in the right upper lobe, identified via CT scan.
CT-guided biopsy confirmed malignant cells with sarcomatous components.

Findings:

Surgical resection (right upper lobectomy, lymph node dissection, chest wall resection) was performed for pathological stage IIB (T3N0M0) BPB.
Histopathology revealed immature mesenchymal and epithelial elements resembling embryonic lung.
Tumor recurrence in supraclavicular lymph nodes occurred within two months post-surgery.

Implications:

This case underscores the aggressive nature of biphasic pulmonary blastoma, even after aggressive treatment.
The rapid progression and early recurrence suggest limited efficacy of current therapeutic strategies for advanced BPB.
Further research into novel therapeutic targets and treatment modalities for BPB is warranted.