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Related Experiment Video

Updated: Jun 25, 2026

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Published on: March 14, 2017

[Rare cause of hypercalcemia].

C Spielhagen¹, A Stier, K Hegenscheid

¹Klinik und Poliklinik für Innere Medizin A, Ernst-Moritz-Arndt Universität Greifswald, Fr.-Loeffler-Strasse 23a, 17475, Greifswald, Deutschland.

|February 14, 2009

Summary

A rare parathyroid carcinoma, initially misdiagnosed as a benign thyroid adenoma, caused metastatic disease and hypercalcemia. Surgical removal of metastases normalized calcium levels, highlighting the importance of accurate diagnosis.

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Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

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Published on: March 14, 2017

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

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Published on: May 31, 2016

Area of Science:

Endocrinology
Oncology
Pathology

Background:

Parathyroid carcinoma is a rare endocrine malignancy.
Accurate diagnosis is challenging due to the absence of pathognomonic criteria.
It often presents with hypercalcemia and can metastasize.

Observation:

A 47-year-old woman presented with unexplained weight loss and hypercalcemia.
Imaging revealed bilateral pulmonary metastases.
Histology of a metastasis indicated an endocrine tumor with low parathyroid hormone expression.

Findings:

The patient was diagnosed with functioning parathyroid carcinoma metastasized eight years after being labeled with a benign thyroid adenoma.
Surgical resection of all metastases was performed.
Post-surgery, serum calcium and parathyroid hormone levels normalized.

Implications:

This case underscores the diagnostic challenges in parathyroid carcinoma.
Surgical resection is the primary treatment modality.
Effective management is crucial to prevent mortality from hypercalcemia.