Multi-objective blood glucose control for type 1 diabetes
Related Experiment Video
Updated: Jun 25, 2026

Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
Pinky Dua1, Francis J Doyle, Efstratios N Pistikopoulos
1Department of Chemical Engineering, Centre for Process Systems Engineering, Imperial College London, South Kensington Campus, London SW72AZ, UK. Pinky.2.dua@gsk.com
Abstract:
For people with type 1 diabetes, automatic controllers aim to maintain the blood glucose concentration within the desired range of 60-120 mg/dL by infusing the appropriate amount of insulin in the presence of meal and exercise disturbances. Blood glucose concentration outside the desired range can be harmful to an individual's health but concentration below 60 mg/dL, a state known as hypoglycemia, is considered to be more harmful than the concentration above 120 mg/dL, a state known as hyperglycemia. In this paper, two techniques to address this issue within a multi-parametric model based control framework are presented. The first technique introduces asymmetry into the objective function to penalize the deviation towards hypoglycemia more than the deviation towards hyperglycemia. The second technique is based upon placing higher priority on satisfaction of constraints on hypoglycemia than on satisfaction of constraints on hyperglycemia. The performance of both the control techniques is analyzed and compared in the presence of disturbances.
Related Concept Videos
Diabetes: Management and Pharmacotherapy
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Diabetes Mellitus: Type 2 and Gestational
Hormones Regulating Blood Glucose
In addition to accelerating glucose uptake and utilization, insulin has...
Hyperglycemia
Type I Diabetes I: Introduction