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Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug binding...
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...

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Usefulness of Clot Waveform Analysis-Activated Thromboplastin Time (APTT) for Diagnosing Thrombotic Diseases.

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Related Experiment Video

Updated: Jun 25, 2026

Application of Hemostatic Devices in Laparoscopic Hepatectomy
04:23

Application of Hemostatic Devices in Laparoscopic Hepatectomy

Published on: April 19, 2022

Hemostatic abnormalities and liver diseases.

Hideo Wada1, Masanobu Usui, Nobuo Sakuragawa

  • 1Departments of Molecular and Laboratory Medicine, Mie University Graduate School of Medicine, Tsu-city, Japan. wadahide@clin.medic.mie-u.ac.jp

Seminars in Thrombosis and Hemostasis
|February 14, 2009
PubMed
Summary

Professor Mammen

Area of Science:

  • Hematology
  • Hepatology
  • Clinical Biochemistry

Background:

  • Liver function is critical for hemostasis, producing key clotting and fibrinolytic factors.
  • Liver diseases and surgery significantly impact coagulation, fibrinolysis, and platelet function.
  • Hepatic failure presents hemostatic abnormalities resembling disseminated intravascular coagulation.

Purpose of the Study:

  • To summarize Professor Mammen's contributions to understanding hemostatic abnormalities in liver disease.
  • To highlight the link between liver function and the hemostatic system.
  • To review the classification and impact of liver conditions on coagulation.

Main Methods:

  • Review of Professor Mammen's research on hemostasis and liver disease.
  • Analysis of hemostatic abnormalities in various liver conditions and surgical contexts.

Related Experiment Videos

Last Updated: Jun 25, 2026

Application of Hemostatic Devices in Laparoscopic Hepatectomy
04:23

Application of Hemostatic Devices in Laparoscopic Hepatectomy

Published on: April 19, 2022

  • Examination of the role of vitamin K-dependent factors and antithrombin.

    • Main Results:

    • Liver diseases and surgery cause diverse hemostatic abnormalities affecting coagulation, fibrinolysis, platelets, and the reticuloendothelial system.
    • Hepatic failure-associated hemostatic issues share similarities with disseminated intravascular coagulation.
    • Research informed the development of diagnostic and therapeutic tools like PT-INR and antithrombin therapy.

    Conclusions:

    • Professor Mammen's work significantly advanced the understanding of hemostasis in liver disease.
    • Effective management of liver disease requires addressing associated hemostatic derangements.
    • His research laid groundwork for modern diagnostic and therapeutic strategies in thrombosis and hemostasis.