Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Antifungal Agents

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...

Antiprotozoal Agents

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...

Anthelminthic Agents

Anthelminthic Agents

Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Monoterpene-indole alkaloid from <i>Rinorea yaundensis</i> and antidiabetic potential of its hydrochloride.

Zeitschrift fur Naturforschung. C, Journal of biosciences·2026

Same author

Isolation, RP-UHPLC-ESI-LIT-Orbitrap-MS/MS-Based Metabolic Profiling and Anticandidal Activity of the Root and Leaf Secondary Metabolites of Monotes Kerstingii Gilg (Dipterocarpaceae).

Chemistry & biodiversity·2026

Same author

Molecularly imprinted polymer-based HPLC column and smart syringe for selective extraction of quercetin from complex plant extracts: A sustainable and green approach.

Journal of chromatography. A·2025

Same author

Oleanane glycosides from a Lebanese edible plant: Gundelia tournefortii L. (Asteraceae).

Fitoterapia·2025

Same author

Three New Triterpene Glycosides from the Roots of <i>Deutzia</i> x <i>Hybrida</i> "Strawberry Fields" (Hydrangeaceae).

Molecules (Basel, Switzerland)·2024

Same author

Valorization of hydro-distillate of fruit peels of <i>Citrus paradisi</i> macfad. Cultivar. Foster: Chemical profiling, antioxidant evaluation and in vitro and in silico enzyme inhibition studies.

Heliyon·2024

Search research articles

Related Experiment Video

Updated: Jun 25, 2026

An Efficient and Rapid HPLC-QQQ-MS Method for the Quantitation of Tropane Alkaloids in Medicinal Plants

An Efficient and Rapid HPLC-QQQ-MS Method for the Quantitation of Tropane Alkaloids in Medicinal Plants

Published on: June 12, 2026

Antimicrobial pentacyclic triterpenoids from Terminalia superba.

Turibio Kuiate Tabopda¹, Joseph Ngoupayo, Sheraz A Khan Tanoli

¹Département de Chimie Organique, Université de Yaoundé I, Yaoundé, Cameroon.

|February 14, 2009

Summary

Four new triterpene glucosides were isolated from Terminalia superba stem bark. These compounds, along with a known triterpene, were tested for antibacterial activity against various bacterial strains.

Related Experiment Videos

Last Updated: Jun 25, 2026

An Efficient and Rapid HPLC-QQQ-MS Method for the Quantitation of Tropane Alkaloids in Medicinal Plants

An Efficient and Rapid HPLC-QQQ-MS Method for the Quantitation of Tropane Alkaloids in Medicinal Plants

Published on: June 12, 2026

Area of Science:

Natural Products Chemistry
Pharmacognosy
Medicinal Chemistry

Background:

The stem bark of Terminalia superba is a potential source of bioactive compounds.
Triterpenes and their glycosides are known for diverse biological activities, including antimicrobial properties.

Purpose of the Study:

To isolate and characterize new triterpene glucosides from Terminalia superba.
To evaluate the antibacterial potential of isolated compounds.

Main Methods:

Bioassay-guided fractionation of methanol extract from Terminalia superba stem bark.
Structure elucidation using spectroscopic methods (NMR, MS).
Antibacterial activity testing against Gram-positive and Gram-negative bacteria.

Main Results:

Four new triterpene glucosides (1-4) and one known triterpene (5) were isolated and characterized.
The isolated compounds (1-5) were evaluated for their antibacterial activity.
Specific activities against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Shigella flexenari, Pseudomonas aeruginosa, and Salmonella typhi were determined.

Conclusions:

Terminalia superba stem bark yields novel triterpene glucosides.
The isolated compounds possess antibacterial properties, warranting further investigation for potential therapeutic applications.