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Published on: March 29, 2022
Largamides A-C, tiglic acid-containing cyclodepsipeptides with elastase-inhibitory activity from the marine
Susan Matthew1, Valerie J Paul, Hendrik Luesch
1Department of Medicinal Chemistry, University of Florida, Gainesville, Florida 32610, USA.
Abstract:
Three unusual tiglic acid-containing cyclodepsipeptides, possessing the revised regioisomeric structures for largamides A-C (1-3), have been isolated from the marine cyanobacterium Lyngbya confervoides collected from southeastern Florida. The two-dimensional structures were determined by NMR spectroscopy and the absolute configurations by chiral HPLC analysis of degradation products. Compounds 1-3 are moderate inhibitors of mammalian elastase activity in vitro with IC(50) values ranging from 0.53 to 1.41 microM.
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