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Published on: May 19, 2023
FGF23 is a putative marker for bone healing and regeneration
Sascha Goebel1, Jasmin Lienau, Ulrich Rammoser
1Orthopedic Center for Musculoskeletal Research, University of Wuerzburg, Wuerzburg, Germany.
Summary
Fibroblast growth factor 23 (FGF23) shows elevated levels during bone healing and may predict fracture union. This phosphatonin is produced by osteoblasts and aids in bone repair processes.
Area of Science:
- Biochemistry
- Orthopedics
- Endocrinology
Background:
- Fibroblast growth factor receptor (FGFR) signaling is crucial for bone remodeling and fracture healing.
- FGF23, a phosphatonin from osteoblasts, signals through FGFR1, impacting bone and kidney function.
Purpose of the Study:
- To investigate serum FGF23 levels as a potential predictor of fracture healing and union.
- To analyze the role of FGF23 in bone healing processes.
Main Methods:
- Measured serum FGF23 (C-Term and intact) in patients undergoing hip arthroplasty.
- Assessed FGF23 mRNA expression and immunohistochemical localization in ovine osteotomy healing models.
- Monitored serum phosphate and phosphate clearance.
Main Results:
- Elevated FGF23 (C-Term) levels were observed postoperatively in hip implant patients.
- FGF23 mRNA expression was significantly higher in standard osteotomy healing compared to delayed healing.
- Osteoblasts and granulation tissue in fracture callus demonstrated FGF23 production.
Conclusions:
- FGF23 is implicated in the bone healing process.
- Serum FGF23 is measurable and shows potential as a biomarker for predicting fracture healing outcomes, distinguishing between union and nonunion.
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