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Updated: Jun 25, 2026
Enhancement of Facial Rejuvenation Through a Combination of 1565 nm Non-Ablative Fractional Laser with 30% Supramolecular Salicylic Acid
Published on: September 27, 2024
A prospective study of fractional scanned nonsequential carbon dioxide laser resurfacing: a clinical and
Alexander L Berlin1, Mussarrat Hussain, Robert Phelps
1Skin Laser and Surgery Specialists of NY and NJ, New York, New York, USA.
Background:
Although unparalleled in its efficacy, carbon dioxide (CO2) laser resurfacing has a high risk:benefit ratio. A modified device uses a novel handpiece and software to deliver nonsequential fractional ablative CO2 laser exposures.
Objective:
To evaluate the safety and efficacy of this fractional ablative, scanned, nonsequential CO2 laser in the treatment of photo-damaged skin and to evaluate histologic and ultrastructural changes after the treatment.
Materials And Methods:
Ten subjects with Fitzpatrick skin types I to III with photo-damaged facial skin underwent a single CO2 ablative laser treatment using a scanning handpiece in a nonsequential fractional mode. Clinical improvement and histologic and ultrastructrural changes were assessed.
Results:
All subjects completed the study with no serious or long-term complications. Blinded evaluator and subject assessment documented improvement in cutaneous photoaging. Light microscopy revealed changes consistent with a wound repair mechanism, and electron microscopy confirmed evidence of new collagen deposition.
Conclusion:
Nonsequential scanned fractional CO2 laser resurfacing can lead to improvement in photo-damaged skin, accompanied by histologic and ultrastructural evidence of wound repair and subsequent new collagen formation.
