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Updated: Jun 25, 2026

Cavernous Nerve Stimulation and Recording of Intracavernous Pressure in a Rat

Cavernous Nerve Stimulation and Recording of Intracavernous Pressure in a Rat

Published on: April 23, 2018

Patient-reported pain with initial intracavernosal injection.

Jeffrey Albaugh¹, Carol Estwing Ferrans

¹Department of Sexual Health Program, Northwestern Memorial Wellness Institute and Jesse Brown VA Medical Center, Chicago, IL 60611, USA. jaalbaug@nmh.org

The Journal of Sexual Medicine

|February 14, 2009

Summary

Men undergoing intracavernosal injections for erectile dysfunction report minimal pain from needle insertion and medication. This study aims to alleviate fears associated with penile injections for improved treatment adherence.

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Area of Science:

Urology
Andrology
Sexual Medicine

Background:

Intracavernosal injections are effective for erectile dysfunction (ED).
Patient reluctance stems from the fear of needle insertion into the penis.
Quantifying pain perception is crucial for patient acceptance and adherence.

Purpose of the Study:

To assess the severity of pain during initial intracavernosal self-injections for ED.
To differentiate pain experienced from needle insertion versus medication.
To provide data to mitigate patient anxiety regarding injection therapy.

Main Methods:

Descriptive study involving 65 men with ED undergoing self-injection therapy.
Pain was self-reported immediately after needle insertion and 10-20 minutes post-injection.

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Cavernous Nerve Stimulation and Recording of Intracavernous Pressure in a Rat

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Development of Recombinant Proteins to Treat Chronic Pain

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A 0-10 verbal pain rating scale was used to evaluate both needle and medication pain.

Main Results:

Mean pain for needle insertion was 0.80 (SD=0.81); 40% reported no pain.
Mean pain for medication was 0.92 (SD=1.5); 64.6% reported no pain.
Men post-radical prostatectomy reported significantly more medication pain (51.9% vs. 23.7%, P=0.02).

Conclusions:

Most patients experience minimal to no pain from intracavernosal injections.
Pain severity, when present, is generally low, addressing a key patient concern.
Consider lower initial medication dosages for post-prostatectomy patients due to higher pain incidence.