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Related Experiment Video

Updated: Jun 25, 2026

On-Site Sampling and Extraction of Brain Tumors for Metabolomics and Lipidomics Analysis
06:48

On-Site Sampling and Extraction of Brain Tumors for Metabolomics and Lipidomics Analysis

Published on: May 31, 2020

Gliosarcoma: clinical experiences and additional information with MR spectroscopy.

Ralf Buhl1, Andreas Martin Stark, Heinz Hermann Hugo

  • 1Department of Neurosurgery, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Kiel, Germany. r.buhl@clemenshospital.de

Neurological Research
|February 14, 2009
PubMed
Summary

Gliosarcomas, a rare glioblastoma subtype, present with mixed glial and sarcomatous features. These rare brain tumors have a poor prognosis, similar to glioblastoma multiforme, with a median survival of 7 months.

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Area of Science:

  • Neuro-oncology
  • Pathology
  • Neurosurgery

Background:

  • Gliosarcomas are rare malignant brain tumors, comprising approximately 2% of glioblastoma multiforme (WHO grade IV) cases.
  • They exhibit a unique combination of glial and sarcomatous cellular components.
  • Clinical presentation and prognosis are generally comparable to those of glioblastoma multiforme.

Purpose of the Study:

  • To analyze the clinical characteristics, treatment, and outcomes of patients with intracranial gliosarcoma.
  • To identify potential pre-operative diagnostic indicators for gliosarcoma.
  • To underscore the poor prognosis and the need for further research.

Main Methods:

  • Retrospective analysis of 16 patients diagnosed with intracranial gliosarcoma between 1997 and 2006.

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The In ovo CAM-assay as a Xenograft Model for Sarcoma
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The In ovo CAM-assay as a Xenograft Model for Sarcoma

Published on: July 17, 2013

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Last Updated: Jun 25, 2026

On-Site Sampling and Extraction of Brain Tumors for Metabolomics and Lipidomics Analysis
06:48

On-Site Sampling and Extraction of Brain Tumors for Metabolomics and Lipidomics Analysis

Published on: May 31, 2020

The In ovo CAM-assay as a Xenograft Model for Sarcoma
12:44

The In ovo CAM-assay as a Xenograft Model for Sarcoma

Published on: July 17, 2013

  • Review of clinical data, including age, sex, tumor location, and treatment.
  • Histopathological examination including glial fibrillary acid protein (GFAP) and MIB-1 proliferation index.
  • Pre-operative magnetic resonance (MR) spectroscopy in two cases.

    • Main Results:

    • Median patient age was 63 years (range 52-79); 11 males and 5 females.
    • Tumor locations varied, with the frontal lobe being the most common site (n=6).
    • Median survival time was 7 months (range 2-11 months).
    • Histology confirmed glial cells positive for GFAP within sarcomatous tissue.
    • MIB-1 proliferation index ranged from 20% to 70%.
    • MR spectroscopy revealed lactate peaks, indicative of necrosis and hypoxia.

    Conclusions:

    • Gliosarcoma remains a rare and aggressive brain tumor with a poor prognosis.
    • Pre-operative MR spectroscopy and tumor characteristics like location near the dura and inhomogeneous contrast enhancement may suggest gliosarcoma.
    • Adjuvant chemotherapy studies are warranted to improve outcomes for patients with gliosarcoma.