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First identification of metallo-beta-lactamase-producing Pseudomonas aeruginosa in the Czech Republic

J Hrabák1, M Fridrichová, M Stolbová

  • 1Department of Microbiology, Faculty of Medicine and University Hospital in Plzen, Charles University in Prague, Plzen, Czech Republic.

Euro Surveillance : Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin
|February 14, 2009
PubMed

Insights

Metallo-beta-lactamase (MBL) producing Pseudomonas aeruginosa strains were absent in the Czech Republic for three years. Two IMP-7 MBL-producing strains were detected in 2008, highlighting the emergence of antibiotic resistance.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Pseudomonas aeruginosa is a significant opportunistic pathogen.
  • Invasive isolates are monitored in the Czech Republic via the European Antibiotic Resistance Surveillance System (EARSS) since 2005.
  • Surveillance covers 48 laboratories and approximately 81% of the population, analyzing blood and cerebrospinal fluid isolates.

Observation:

  • Over a three-year period, 1,259 invasive Pseudomonas aeruginosa isolates were tested.
  • No metallo-beta-lactamase (MBL) producing strains were detected until mid-2008.
  • Two MBL-producing strains were identified in isolates from a single regional hospital.

Findings:

  • The detected metallo-beta-lactamase was identified as IMP-7.
  • IMP-7 is a carbapenemase previously reported in Canada, Japan, Malaysia, and Slovakia.
  • This marks the first detection of MBL-producing Pseudomonas aeruginosa in invasive isolates in the Czech Republic.

Implications:

  • The emergence of IMP-7 in the Czech Republic necessitates enhanced surveillance for MBL-producing bacteria.
  • This finding underscores the dynamic nature of antimicrobial resistance spread across geographical regions.
  • Understanding the epidemiology of IMP-7 is crucial for guiding infection control strategies and antibiotic stewardship.

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