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Physico-chemical and structural characterization of diacerhein
Massimo Bambagiotti-Alberti1, Gianluca Bartolucci, Bruno Bruni
1Dipartimento di Scienze Farmaceutiche, Università di Firenze, Sesto Fiorentino (Florence), Italy.
Abstract:
The physico-chemical and structural characterization of diacerhein, an anthraquinone with antiinflammatory activity, employed in the symptomatic treatment of inflammatory osteoarthritis, is reported. The combined use of FT-IR, DSC, X-ray powder and single-crystal diffraction has provided a valuable tool to fully characterize the title compound. The X-ray diffraction study has revealed the existence of hydrogen-bond assisted tight packing of the quasi-planar molecules in the solid. The collected results are intended to implement the information required for the compilation of drug master files.
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